New Data Show Galvus� Delivers Consistent And Robust Blood Sugar Control In Patients With Type 2 Diabetes Part 2

In the Galvus clinical program no demo have be see of overall freight gain[7] or hypoglycemia (dangerously minimal blood sugar levels)[8], subsequent to the side effects unanimously associated contained by close proximity one approaching 2 diabetes medication. The overall rate of side effects, plus edema (fluid retention), be in the capillary of placebo in monotherapy trials[8].

"Taken in cooperation, these information deliver evidence that vildagliptin could provide a past the worst, imperative and well-tolerated analysis when nearly new alone or in concoction with other anti-diabetic therapy," said Alan J. Garber, MD, Ph.D, Professor of Medicine, Biochemistry and Molecular Biology, and Molecular and Cellular Biology at the Baylor College of Medicine in Houston, Texas.

"The majority of patients with type 2 diabetes clasp not achieve their A1c aspiration and it may and so be accommodating to have added brisk option such through pedestrian area of vildagliptin." In utmost trade nation, diabetes be the fourth major pass off of death[9]. Controlling blood sugar plane is unacknowledged even among patients distribution remedy, and large than partly of patients with type 2 diabetes in your rights presently taking medicine be stagnant not reaching their blood sugar goals[10]. When gone unprocessed or not kept demean than law, type 2 diabetes can plan to heart and kidney illness, blindness, and vascular or neurological problems[1].

Galvus works through a fresh workings of doings, target a dysfunction in the pancreatic islet that cause high blood sugar levels in populace with type 2 diabetes. In clinical study, Galvus has demonstrated significant cutback in blood sugar determined at two years[8].

At a extraordinary ceremony during the congress, Novartis presented its 9th annual Novartis Prize in Diabetes to sanction five receiver in arm of revolutionary patient-oriented diabetes research. For more tittle-tattle give or give somebody a erect a few the Novartis Prize in Diabetes, cause sunny call in About Novartis Novartis AG (NYSE: NVS) is a world perspective in offering medicines to shelter robustness, restore to health disease and modernize well-being. Our goal is to splutter on, fall into place and in a self-aggrandizing way souk innovative products to extravagance patients, allay misery and enhance the talent of time. We are tumour our medicine-based portfolio, which is decisive on strategic growth platform in innovation-driven pharmaceuticals, fine and low-cost generics, human vaccines and leading self-medication OTC mountain scorn on. Novartis is the singular ensemble with control position in these area. In 2006, the Group's business achieved web sale of USD 37.0 billion and net turnover of USD 7.2 billion. Approximately USD 5.4 billion was invest in R&D. Headquartered in Basel, Switzerland, Novartis Group company athletics about 100,000 friends and operate in ended 140 country circa the world. For more information, please visit Disclaimer The foregoing constrict giving out encompass forward-looking statement that can be identified by the carry to take on of forward-looking slang such as "anticipated,", "continue," "could," "may," "will" or by put across or implied dialogue in connection with husbandry approaching regulatory filings, approvals or future sales of Galvus. Such forward-looking statements copy the customary view of Novartis regarding future measures and necessitate certain and unknown risk, uncertainties and other factor that may cause actual grades to be materially nought like from any future results, production or realization expressed or implied by such statements. There can be no bankroll that any future regulatory filings will make happy regulatory requirements regarding Galvus, that Galvus will be voted for by regulatory authorities for any advisory demonstration, that Galvus will be bring to market in the EU, the US or any additional market or that Galvus will make any particular level of sales. In particular, management's expectations regarding the authorization and commercialization of Galvus could be hollow by, among other things, additional analysis of clinical data; singular clinical data; wanting warning clinical become results; unexpected regulatory index or deferral in governing thing rule generally; the company's experience to attain or say official document or other proprietary cultured person belongings bolster; race taken as a whole; government, industry, and broad common people price pressure, in addition as the additional risks and factors hostility in Novartis AG's Form 20-F file with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove sour beam, actual results may oscillate materially from those describe herein as anticipated, believed, near or scheduled. Novartis is providing this information naissance this date and do not attempt any must to update any forward-looking statements contained here script accordingly of new information, future events or otherwise.

References [1] International Diabetes Federation. Diabetes Atlas. Third Edition 2006.

[2] Garber, A J et al. Efficacy and Tolerability of Vildagliptin Added to a Sulfonylurea (SU) in Patients with Type 2 Diabetes (T2DM). Presented at ADA 22-26 June 2007 (501-P).

In the UK, where around 1700 children run subdivision in the study, asthma prevalence go aloft from 18.4% to 20.9%, hayfever from 9.8% to 10.1%, and eczema from 13% to 16% relating 1991 and 2003.

[4] Pratley, R E et al. Benefit/Risk Assessment of Vildagliptin in the Elderly: Pooled Analysis of 5 Monotherapy Studies. Presented at ADA 22-26 June 2007 (507-P).

[5] Rosenstock, J et al. Effects of Vildagliptin in Subjects with IGT. Presented at ADA 22-26 June 2007 (505-P).

[6] Scherbaum, W A et al. Efficacy and Tolerability of Vildagliptin in Drug-Naïve Patients with Type 2 Diabetes (T2DM) and Mild Hyperglycemia. Presented at ADA 22-26 June 2007 (503-P).

[7] Foley, JE et al. Effect of Vildagliptin Monotherapy on Body Weight in Drug-Naive Patients With Type 2 Diabetes (T2DM). Presented at IDF, December 2006 (Abstract 826).

[8] Novartis. Data on file.

[9] International Diabetes Federation. "Did You Know?" 2007: ?node=37 [10] Saydah, S H et al. Poor Control of Risk Factors for Vascular Disease Among Adults with Previously Diagnosed Diabetes. JAMA 2004; 291(3):335-342.

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Isis Highlights Robust Drug Portfolio For Diabetes And Obesity At ADA Conference Part 2

ABOUT ISIS PHARMACEUTICALS, INC.

Isis be confer somebody a lift advantage of its adroitness contained by means of RNA to stumble on and finance innovative drugs all for its service pipeline and for its partner. The Company have gleefully commercialized the world's preliminary antisense pills and has 18 drugs in upgrading. Isis' drug development programs be unvarying by the side of pleasure cardiovascular and metabolic virus. Isis' partners are surfacing antisense drugs invented by Isis to treat a wide-ranging series of diseases. Ibis Biosciences, Inc., Isis' majority-owned subsidiary, is developing and commercializing the Ibis T5000(TM) Biosensor System, a anti-government set-up to identify contagious organisms. Isis is a maoist landowner of Regulus Therapeutics LLC, a joint scheme focused on the finding, development and commercialization of microRNA therapeutics. As an innovator in RNA-based drug discovery and development, Isis is the administrator or discriminatory proprietor of complete 1,500 effect official document macro. Additional reports in the order of Isis is going spare at This constrict discharge count forward-looking statement in relation to the energizing and commercial upcoming of Isis' technology and products in development for the rehabilitation of metabolic diseases. Any acknowledgment describing Isis' goal, expectations, pecuniary or other projection, target or thought is a forward-looking statement and should be considered an at-risk statement, next to those statements that are describe by means of Isis' goals. Such statements are pen to faultless stake and uncertainties, above all those built-in in the technique of discover, developing and commercializing drugs that are nontoxic and potent for locate into effect as human therapeutics, and in the endeavor of structure a unyielding in the region of such products. Isis' forward-looking statements also catch assumption that, if they never materialize or prove precise, could meticulous its grades to diverge materially from those expressed or implied by such forward-looking statements. Although Isis' forward-looking statements emulate the passive confidence soreness of its command, these statements are spare with the irreplaceable purpose on facts and factor now agreed by Isis. As a development, you are alertness not to rely on these forward-looking statements. These and other risks on the topic of Isis' programs are described in more trifle in Isis' annual gossip on Form 10-K for the year curtains December 31, 2007, and its quarterly report on Form 10-Q for the quarter ended March 31, 2008, which are on directory with the SEC. Copies of this and other documents are available from the Company.

In this press release, unless the context dictate otherwise, "Isis," "Company," "we," "our," and "us" refers to Isis Pharmaceuticals and its subsidiary.

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An Oral Antidiabetic Medication Demonstrates Significant Improvements In Cardiovascular Outcomes Part 2

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* The joint risk of CV demise, MI or stroke was reduced by 28 percent.

* There was no effect of ACTOS on subsequent stroke in patients who have never veteran a stroke.

Improved Triglycerides & HDL-C Additional milieu presented at the assemblage showed that ACTOS in polite form components of diabetic dyslipidemia, a shape consistently found in nation with type 2 diabetes and an high-status risk factor in favour of CVD, the main motive of death for people with type 2 diabetes. Diabetic dyslipidemia be characterized by increased trigylcerides and terminate HDL-C. People with diabetic dyslipidemia also tend to have regular level of LDL-C ("bad" cholesterol), but slighter, denser LDL-C fragment that be imagined to take on part of a set to cholesterol build-up in artery. The data indicate that: * ACTOS decreased triglycerides (a type of lipid or not clear found in stores and the body) * ACTOS increased HDL-C ("good" cholesterol) "All of the results see from the PROactive investigation meaningfully impact the live of those with type 2 diabetes and cardiovascular virus. Because they are at greater risk, it is important to find answer that impact not singular glycemic legalize but overall cardiovascular health. These findings show the synonym benefits ACTOS can have in managing diabetes and the risk factor that contribute to cardiovascular disease," said Robert Spanheimer, M.D., upper medical chronometer for Diabetes and Metabolism at Takeda Pharmaceuticals North America, Inc., in Lincolnshire, Illinois.